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許昺奇 特聘教授兼環境健康與生物科技研究中心主任

許昺奇
許昺奇

學歷

  • 國立成功大學基礎醫學研究所博士
  • 中國醫藥學院環境醫學研究所碩士
  • 中國醫藥學院公共衛生學系學士

聯絡方式

經歷

  • 美國德州大學西南醫學中心 訪問學者(2023/02-2023/07)
  • 國立高雄科技大學環境與安全衛生工程系 教授(2005/02迄今)
  • 國立高雄科技大學環境健康與生物科技研究中心 主任(2013/02迄今)
  • 國立高雄第一科技大學通識教育中心 中心主任(2017/02-2018/02)
  • 國立高雄第一科技大學環境與安全衛生工程系 特聘教授(2015/01-2017/12)
  • 國立高雄第一科技大學環境與安全衛生工程系 教授兼系主任(2007/0801-2010/07/31)
  • 國立高雄第一科技大學環境與安全衛生工程系 教授(2005/0201-)
  • 國立高雄第一科技大學環境與安全衛生工程系 副教授(2001/0101-2005/0131)
  • 國立高雄第一科技大學環境與安全衛生工程系 助理教授(1999/0801-2000/1231)
  • 嘉南藥理科技大學職業安全衛生系 助理教授(1998/0801-1999/0731)
  • 工礦衛生技師(七十九年專門職業與技術人員高等考試)
  • 工業安全技師(八十一年專門職業與技術人員高等考試)

專長

  • 工業衛生
  • 環境衛生
  • 環境毒理
  • 生殖危害評估

研究方向

過去在【環境荷爾蒙污染與健康危害】領域之研究成果豐碩，已發表多篇國際科學期刊論文。近年來的研究主軸為『環境與職業毒性化學物質暴露對雄性生殖系統影響之研究』，由較早期的動物模式之建立，逐漸推展到人類健康評估，並針對精子功能之評估逐年建立與國際研究水準同步之實驗品質。雄性生殖系統是極為敏感的毒性作用終點之一，因此『應用雄性生殖系統危害評估技術，將可做為評估暴露環境與職業毒性化學物質引發健康危害之早期與敏感標記』。建立環境持久性有機污染物質(persistent organic pollutants, POPs)或新興污染物質(emerging compounds, ECs)之生殖危害評估，已逐漸受到科學界之重視。此外也針對職業毒性化學物質暴露進行雄性生殖毒理之研究，包括暴露多溴聯苯醚(polybrominated diphenylethers, PBDEs)、多氯聯苯(Polychlorinated biphenyls, PCBs)、多環芳香族碳氫化合物(polycyclic aromatic hydrocarbons, PAHs)、鉛(lead, Pb)、銦(indium, In)、鄰苯二甲酸酯類(phthalates, PAEs)、三(2-丁氧基乙基)磷酸酯(tris(2-butoxyethyl) phosphate, TBEP)、PM2.5與全氟多氟烷基物質(Per/Poly fluoroalkyl substances, PFAS)等，影響精子功能之系列實驗動物與環境職業流行病學之研究。近年證據顯示環境污染可能影響生殖細胞DNA甲基化改變，與人體健康危害有關。近年來針對多溴聯苯醚、DEHP、與PM2.5等環境內分泌干擾與空氣污染物影響精子功能與DNA甲基化超代表觀遺傳變化研究成果，已陸續發表於頂尖科學期刊，研究成果具有創新性、學術性、實用性及整合性。

期刊論文(Referred Journal Articles)

* Corresponding author.
  1. Lee, C.W., Chen, K.L., Yuan, C.S., Lai, C.S., Tsai, X.Y., Wu, P.H., Hsu, P.C.* (2024) Epigenetic transgenerational effects of PM2.5 collected from southern Taiwan on sperm functions and DNA methylation in mouse offspring. Ecotoxicology and Environmental Safety 269, 115802. (Corresponding author, SCI, Impact factor: 6.8; Ranking: 6/94 (5.9%) of Toxicology in 2022)
  2. Su, H.Y., Lai, C.S., Lee, K.H., Chiang, Y.W., Chen, C.C., Hsu, P.C.* (2024) Prenatal exposure to low-dose di-(2-ethylhexyl) phthalate (DEHP) induces potentially hepatic lipid accumulation and fibrotic changes in rat offspring. Ecotoxicology and Environmental Safety 269, 115776. (Corresponding author, SCI, Impact factor: 6.8; Ranking: 6/94 (5.9%) of Toxicology in 2022)
  3. Huang, J.K., Chuang, Y.S., Wu, P.H., Lin, J.R., Kuo, M.C., Chiu, Y.W., Hsu, P.C., Wu, M.T., Salihovic, S., Lin, Y.T. (2023) Decreased perfluoroalkyl substances found in patients with hemodialysis treatment. Science of the Total Environment 896, 165184. (SCI, Impact factor: 9.8; Ranking: 26/274 (9.5%) of Environmental Sciences in 2022)
  4. Pan, H.Y., Cheng, F.J., Huang, K.C., Kung, C.T., Huang, W.T., You, H.L., Li, S.H., Wang, C.C., Lee, W.C., Hsu, P.C.* (2022) Exposure to tris(2-butoxyethyl) phosphate induces abnormal sperm morphology and testicular histopathology in male rats. Ecotoxicology and Environmental Safety 241, 113718. (Corresponding author, SCI, Impact factor: 6.8; Ranking: 6/94 (5.9%) of Toxicology in 2022)
  5. Yuan, C.S., Lai, C.S., Tseng, Y.L., Hsu, P.C., Lin, C.M., Lee, C.W., Cheng, F.J. (2021) Repeated exposure to fine particulate matter constitutes leading to liver inflammation and proliferative response in mice. Ecotoxicology and Environmental Safety 224, 112636. (SCI, Impact factor: 6.8; Ranking: 6/94 (5.9%) of Toxicology in 2022)
  6. Hsu, P.C., Jhong, J.Y., Huang, L.P., Lee, K.H., Chen, H.P., Guo, Y.L.* (2021) Transgenerational effects of di(2-ethylhexyl) phthalate on anogenital distance, sperm functions and DNA methylation in rat offspring. International Journal of Molecular Sciences 22, 4131. (https://doi.org/10.3390/ijms22084131) (First author, SCI, Impact factor: 5.6; Ranking: 66/285 (23.16%) of Biochemistry and Molecular Biology in 2022)
  7. Hsu, P.C.,* Li, Z.K., Lai, C.S., Tseng, L.H., Lee, C.W., Cheng, F.J., Chang, C.Y., Chen, J.R. (2021) Transgenerational effects of BDE-209 on male reproduction in F3 offspring rats. Chemosphere 272, 129829. (First and corresponding author, SCI, Impact factor: 8.8; Ranking: 30/274 (10.9%) of Environmental Sciences in 2022)
  8. Cheng, F.J., Wu, K.H., Huang, S.C., Lee, K.H., Lee, C.W., Liu, K.Y., Hsu, P.C.* (2020) Association between ambient air pollution and out-of-hospital cardiac arrest: are there potentially susceptible groups? Journal of Exposure Science and Environmental Epidemiology 30, 641-649. (doi:10.1038/s41370-019-0140-7) (Corresponding author, SCI,)
  9. Cheng, F.J., Lee, K.H., Lee, C.W., Hsu, P.C.* (2019) Association between particulate matter air pollution and hospital emergency room visits for pneumonia with septicemia: a retrospective analysis. Aerosol and Air Quality Research 19(2), 345-354. (Corresponding author, SCI)
  10. Chen, H.P., Lee, Y.K., Shi, P.C., Hsu, P.C.,*, Chang, C.F. (2018) Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. Oncotarget 9(17), 13167-13180. (SCI,)
  11. Chen, H.P., Pan, M.H., Chou,Y.Y., Sung, C., Lee, K.H., Leung, C.M., Hsu, P.C.* (2017) Effects of Di(2-ethylhexyl)phthalate Exposure on 1,2-Dimethyhydrazineinduced Colon Tumor Promotion in Rats. Food and Chemical Toxicology 103(1), 157-167. (SCI)
  12. Hsu, P.C., Li, M.C., Lee, Y.C., Kuo, P.L., Guo, Y.L. (2016) Polychlorinated biphenyls and dibenzofurans increased abnormal sperm morphology without alterations in aneuploidy: The Yucheng study. Chemosphere 165(1), 294-297. (SCI)
  13. Hsu, P.C.,* Kuo, Y.T., Guo, Y.L., Chen, J.R., Tsai, S.S., Chao, H.R., Teng, Y.N., Pan, M.H. (2016) The adverse effects of low-dose exposure to di(2-ethylhexyl) phthalate during adolescence on sperm function in adult rats. Environmental Toxicology 31(6), 706-712. (Corresponding author, SCI)
  14. Lee, K.H., Chen, H.L., Leung, C.M., Chen, H.P., Hsu, P.C.* (2016) Indium acetate toxicity in male reproductive system in rats. Environmental Toxicology 31(1), 68-76. (Corresponding author, SCI)
  15. Lee, K.H., Chen, H.L., Leung, C.M., Chen, H.P., Tsai, SS., Hsu, P.C.* (2014) Effects of indium chloride exposure on sperm morphology and DNA integrity in rats. Journal of Food and Drug Analysis 23(1), 152–160. (Corresponding author, SCI)
  16. Liu, P.F., Leung, C.M., Chang, Y.H., Cheng, J.S., Chen, J.J., Weng, C.J., Tsai, K.W., Hsu, C.J., Liu, Y.C., Hsu, P.C., Pan, H.W., Shu, C.W. (2014) ATG4B promotes colorectal cancer growth independent of autophagic flux. Autophagy 10(8), 1454–1465. (SCI)
  17. Lin, D.Y., Lee, Y.P., Li, C.P., Chi, K.H., Liang, B.W.P., Liu, W.Y., Wang, C.C., Lin, S., Chen, T.C., Yeh, K.J.C., Hsu, P,C,, Hsu, Y.C., Chao, H.R., Tsou, T.C. (2014) Combination of a fast cleanup procedure and DR-CALUX® bioassay for dioxin surveillance in Taiwanese soil. International Journal of Environmental Research and Public Health 11(5), 4886-4904. (SCI)
  18. Leung, C.M., Chen, T.W., Li, S.C., Ho, M.R., Hu, L.Y., Liu, W.S., Wu, T.T., Hsu, P.C., Chang, H.T., Tsai, K.W. (2014) MicroRNA expression profiling in human breast cancer cells after multifraction and single dose radiation treatment. Oncology Reports 31(5), 2147-2156. (SCI)
  19. Leung, C.M., Li, S.C., Chen, T.W., Ho, M.R., Hu, L.Y., Liu, W.S., Wu, T.T., Hsu, P.C., Chang, H.T., Tsai, K.W. (2014) Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. Oncology Reports 31(3), 1067-1078. (SCI)
  20. Hsu, P.C.,* Guo, Y.L., Smith, D.R., Lin, Y.S., Tseng, L.H., Lee, C.W., Chen, J.R. (2014) Airborne persistent organic pollutants and male reproductive health. Aerosol and Air Quality Research 14(4), 1292-1298. (Corresponding author, SCI)
  21. Huang, L.P., Lee, C.C., Fan, J.P., Kuo, P.H., Shih, T.S., Hsu, P.C.* (2014) Urinary metabolites of di(2-ethylhexyl) phthalate relation to sperm motility, reactive oxygen species generation, and apoptosis in polyvinyl chloride workers. International Archives of Occupational and Environmental Health 87(6), 635-646. (Corresponding author, SCI)
  22. Tseng, L.H., Hsu, P.C.,* Lee, C.W., Tsai, S.S., Pan, M.H., Li, M.H. (2013) Developmental exposure to decabrominated diphenyl ether (BDE-209): Effects on sperm oxidative stress and chromatin DNA damage in mouse offspring. Environmental Toxicology 28(7), 380-389. (Corresponding author, SCI)
  23. Lin, Y.S., Caffrey, J.L., Hsu P.C., Chang, M.H., Faramawi, M., Lin, J.W. (2012) Environmental exposure to dioxin-like compounds and the mortality risk in the U.S. population. International Journal of Hygiene and Environmental Health 215(6), 541-546. (SCI)
  24. Huang, L.P., Lee, C.C., Hsu, P.C.,* Shih, T.S. (2011) The association between semen quality in workers and the concentration of di(2-ethylhexyl) phthalate in polyvinyl chloride pellet plant air. Fertility and Sterility 96(1), 90-94. (Corresponding author, SCI)
  25. Hsu, P.C., Liu, M.Y., Hsu, C.C., Chen, L.Y. and Guo, Y.L. (1997) Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm. Toxicology122, 133-143. (SCI)
  26. Hsu, P.C., Hsu, C.C., Liu, M.Y., Chen, L.Y. and Guo, Y.L. (1998) Lead-induced changes in spermatozoa function and metabolism. Journal of Toxicology and Environmental Health, Part A, 55, 45-64. (SCI)
  27. Hsu, P.C., Liu, M.Y., Hsu, C.C., Chen, L.Y. and Guo, Y.L. (1998) Effects of vitamin E and/or C on reactive oxygen species-related lead toxicity in the rat sperm. Toxicology 128, 169-179. (SCI)
  28. Hsu, P.C., Hsu, C.C. and Guo, Y.L. (1999) Hydrogen peroxide induces premature acrosome reaction in rat sperm and reduces their penetration of the zona pellucida. Toxicology139, 93-101. (SCI)
  29. Guo, Y.L., Hsu, P.C., Hsu, C.C. and Lambert, G.H. (2000) Sperm quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet356, 1240-1241. (corresponding author, SCI)
  30. Yuan, K., Hsu, P.C., Tseng, C.C., Kiang, D. and Wang, J.R. (2001) Detection rate of Actinobacillus Actinomycetemcomitans on the permanen first molars of primary school children by polymerase chain reaction.Journal of Clinical Periodontology28, 348-352. (SCI)
  31. Yuan, K., Chang, C.J., Hsu, P.C., Sun H.S., Tseng, C.C. and Wang, J.R. (2001) Detection of putative periodontal pathogens in non-insulin-dependent diabetes mellitus by polymerase chain reaction. Journal of Periodontal Research36, 18-24. (SCI)
  32. Chang, H.O., Lin, Y.M., Hsu, P.C. and Guo, Y.L. (2001) Reduction of sperm motility in a male laboratory worker exposed to solvents: A case study. Environmental Health Perspectives 109, 753-756. (SCI)
  33. Li, M.H., Hsu, P.C. and Guo, Y. L. (2001) Hepatic enzyme induction and acute endocrine effects of 2,2’,3,3’,4,6’-hexachlorobiphenyl and 2,2’,3,4’,5’,6-hexachlorobiphenyl in prepubertal female rats. Archives of Environmental Contamination and Toxicology 41, 381-385. (SCI)
  34. Smith, D. and Hsu, P.C. (2001) Occupational health and safety in Taiwan. Journal of Occupational Health and Safety- Australia and New Zealand 17, 1-3.
  35. Hsu, P.C. and Guo, Y.L. (2002) Antioxidant nutrients and lead toxicity. Toxicology 180, 33-44. (SCI)
  36. Hsu, P.C., Li M.H. and Guo Y.L. (2003) Postnatal exposure of 2,2’,3,3’,4,6’ - hexachlorobiphenyl and 2,2’,3,4’,5’,6 - hexachlorobiphenyl on sperm function and hormone levels in adult rats. Toxicology 187, 117-126. (SCI)
  37. Hsu, P.C., Huang, W., Yao, W.J., Wu, M.H., Guo, Y.L. and Lambert, G.H. (2003) Sperm changes in human exposed to polychlorinated biphenyls and dibenzofurans. JAMA-Journal of the American Medical Association 289, 2943-2944. (SCI)
  38. Hsu, P.C., Guo, Y.L. and Li, M.H. (2004) Effects of postnatal exposure to 3,3’,4,4’-tetrachlorobiphenyl on sperm function and hormone levels in adult rats. Chemosphere 54, 611-618. (SCI)
  39. Chang, H.Y., Shih, T.S. Guo, Y.L., Tsai, C.Y. and Hsu, P.C. (2004) Sperm function in workers exposed to N,N-dimethylformamide in synthetic leather industry. Fertility and Sterility 81, 1589-1594. (SCI)
  40. Hsu, P.C., Chen C.J., Hung, P.C., Wang, S., Lin,W.G., Chen, K.H., Guo, H.R. and Guo,Y.L. (2004) Assessment of occupational safety and health management and adverse effects in biotechnology industries. Journal of Occupational Safety and Health12, 172-184.(in Chinese with English abstract)
  41. Hsu, P.C., Huang, Y.T., Tsai, M.L., Wang, Y.J., Lin, J.K. and Pan, M.H. (2004) Induction of apoptosis by shikonin through coordinative modulation of Bcl-2 family, p27, and p53, release of cytochrome c and sequential activation of caspases in human colorectal carcinoma cells. Journal of Agricultural and Food Chemistry 52, 6330-6337. (SCI)
  42. Lay, J.J., Fan, K.S., Hwang, J.I., Chang, J.I. and Hsu, P.C. (2005) Factors affecting the hydrogen production from food wastes by Clostridium-rich composts. Journal of Environmental Engineering 131, 595-602. (SCI)
  43. Pan, M.H., Lai, C.S., Hsu, P.C. and Wang, Y.J. (2005) Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspases cascades and production of reactive oxygen species. Journal of Agricultural and Food Chemistry 53, 620-630. (SCI)
  44. Hsu, P.C., Lai, T.J., Guo, N.W., Lambert G. H. and Guo, Y.L. (2005) Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans. Journal of Toxicology and Environmental Health, Part A 68, 1447-1456. (SCI)
  45. Lay, J. J., Tsai, C. J., Huang, C. C., Chang, J. J., Chou, C. H., Fan K. S., Chang, J. I. and Hsu, P. C. (2005) Influences of pH and hydraulic retention time on anaerobes converting beer processing wastes into hydrogen. Water Science and Technology 52, 123-129. (SCI)
  46. Hsu, P.C., Chen, I.Y., Pan, C.H., Wu, K.Y., Pan, M.H., Chen, J.R., Chen, C.J., Chang-Chien, G.P., Liu, C.S. and Wu, M.T. (2006) Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers. International Archives of Occupational and Environmental Health 79, 349-356. (SCI)
  47. Lin, T.C.E., Chien, S.C., Hsu, P.C. and Li, L.A. (2006) Mechanistic study of PCB126-induced CYP11B1 and CYP11B2 upregulation. Endocrinology 147, 1536-11544. (SCI)
  48. Tseng, L.H., Lee, C.W., Pan, M.H., Tsai, S.S., Li, M.H., Chen, J.R., Lay, J.J. and Hsu, P.C.* (2006) Postnatal exposure of the male mouse to 2,2’,3,3’,4,4’,5,5’,6,6’-decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis. Toxicology 224, 33-43.(corresponding author, SCI)
  49. Pan, M.H., Huang, Y.T., Ho, C.T., Chang, C.I., Hsu, P.C. and Pan, B.S. (2006) Induction of apoptosis by Meretrix lusoria through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia cells. Life Sciences79, 1149-1152. (SCI)
  50. Chang, J.J., Chou, C.H., Hsu, P.C., Yu, S.J., Chen, W.E., Lay, J.J., Huang, C.C. and Wen, F.S. (2007) Flow-FISH analysis and isolation of clostridial strains in an anaerobic semi-solid bio-hydrogen producing system by hydrogenase gene target. Applied Microbiology and Biotechnology 74, 1126-1134. (SCI)
  51. Hsu, P.C., Pan, M.H., Li, L.A., Chen, C.J., Tsai, S.S., Guo, Y.L. (2007) Exposure in utero to 2,2',3,3',4,6'-hexachlorobiphenyl (PCB 132) impairs sperm function and alters testicular apoptosis-related gene expression in rat offspring. Toxicology and Applied Pharmacology 221, 68-75. (SCI)
  52. Hsu, B.M., Wun, H.Y., Hsu, P.C. (2007) Prevalence and genotyping of Giardia in husbandry systems in Taiwan.Parasiology Research 101, 275-280. (SCI)
  53. Chen, J.R., Tsai, H.Y., Hsu, P.C. and Shen, C.C. (2007) Estimation of waste generation from floods. Waste Management 27, 1717-1724. (SCI)
  54. Cheng, A.C., Jian, C.B., Huang, Y.T., Lai, C.S., Hsu, P.C. and Pand, M.H. (2007) Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells. Food and Chemical Toxicology 45, 2206-2218. (SCI)
  55. Tseng, L.H., Li, M.H., Tsai, S.S., Lee, C.W., Pan, M.H. and Hsu, P.C.* (2008) Developmental exposure to decabromodiphenyl ether (PBDE 209): Effects on thyroid hormone and hepatic enzyme activity in male mouse offspring. Chemosphere 70, 640-647. (corresponding author, SCI)
  56. Hsu, P.C., Chang, H.Y., Guo, Y.L., Liu, Y.C. and Shih, T.S. (2008) Effect of smoking on blood lead levels in workers and role of reactive oxygen species in lead-induced sperm chromatin DNA damage. Fertility and Sterility91, 1096-1103. (SCI)

研討會論文(Conference papers)

  1. Shiau G.F., Hsu P.C., Lin C.I. and Guo Y.L. (2000) " The effects of ultrahigh frequency electromagnetic field exposure on blood pressure and heart rate in male SD rats", Congress on Industrial Health, April 1-2, Taipei, Taiwan.
  2. Hsu P.C., Zu W.Z., Wang C.Z., Lin S.H. and Guo Y.L. (2000) "The effects of lead exposure in vitro on sperm motility in male SD rats ", Congress on Industrial Health, April 1-2, Taipei, Taiwan.
  3. Hsu P.C., Liu, M.Y., Hsu, C.C., Chen, L.Y. and Guo, Y.L. (2000) "The animal model studies of effects of lead exposure on sperm function", Congress on Occupational Health, April 29-30, Tainan, Taiwan.
  4. Hsu P.C., Yu, M.L., Lai, T.J., Guo, N.W., Lambert, G.H. and Guo, Y.L. (2000) “Thyroid Hormone Levels in Young men Prenatally Exposed to Polychlorinated Biphenyls and Dibenzofurans”, The 20th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 14-17, Monterey, USA.
  5. Hsu, P.C., Li, M.H., and Guo, Y. L. (2001) “Effects of neonatal exposure to 2,2’,3,3’,4,6’-Hexachlorobiphenyl and 2,2’,3,4’,5’,6-Hexachlorobiphenyl on sperm function in male rats”, 16th Joint Annual Conference of Biomedical Science, March 24-25, Taipei, Taiwan.
  6. Hsu, P.C., Li, M.H., and Guo, Y. L. (2001) “Effects of neonatal exposure to 2,2’,3,3’,4,6’-Hexachlorobiphenyl and 2,2’,3,4’,5’,6-Hexachlorobiphenyl on endocrine system in male rats”, Congress on Industrial Hygiene, April 27-29, Kaohsiung, Taiwan.
  7. Shiau, G.F., Hsu, P.C., Guo, Y.L., and Lin, C.I. (2001) “The effects of long-term ultra high frequency electromagnetic field exposure on blood pressure and heart rate in rats”, Congress on Industrial Hygiene, April 27-29, Kaohsiung, Taiwan.
  8. Guo, Y.L., Yu, M.L., Hsu, P.C., Lai, T.J., Rogan, W. J., Hsu, C.C., and Lambert, G.H. (2001) “Reproductive effects of PCBs/PCDFs in Yucheng patients”, The 21st International Symposium on Halogenated Environmental Organic Pollutants and POPs, September 9-14, Gyeogju, Korea.
  9. Hsu, P.C., and Guo, Y.L. (2002) “Lead intoxication: antioxidant defenses and oxidative damage in rat sperm”, 17th Joint Annual Conference of Biomedical Science, March 23-24, Taipei, Taiwan.
  10. Char, Y.Y., Tsai, L.H., and Hsu, P.C.* (2002) “Effects of hydrogen peroxide exposure on DNA integrity in rat spermatozoa”, 17th Joint Annual Conference of Biomedical Science, March 23-24, Taipei, Taiwan.
  11. Tsai, L.H., Char, Y.Y., and Hsu, P.C.* (2002) “Effects of heat exposure on chromatin DNA abnormality in rat spermatozoa: a flow cytometric investigation”, 17th Joint Annual Conference of Biomedical Science, March 23-24, Taipei, Taiwan.
  12. Li, H.F., Shiau, J.C., Fan, K.S., Lay, J.J., and Hsu, P.C.* (2002) “A new method for the flow cytometry analysis of mitochondrial membrane potential using the Mito-Tracker Green”, Congress on Industrial Hygiene, April 26-27, Taipei, Taiwan.
  13. Char, Y.Y., Tsai, L.H., Guo, Y.L., Kuo, P.L., and Hsu, P.C.* (2002) “Protection of ascorbic acid on hydrogen peroxide-induced human sperm DNA damage”, Congress on Industrial Hygiene, April 26-27, Taipei, Taiwan.
  14. Lai, G.X., Huang, X.G., Char, Y.Y., Tsai, L.H., and Hsu, P.C.* (2002) “Effects of heat and ultrasonic vibration treatment on rat sperm DNA structure”, Congress on Industrial Hygiene, April 26-27, Taipei, Taiwan.
  15. Hsu, P.C.,Li, M.H., andGuo Y.L. (2002) “Effects of prenatal exposure of 3,3’,4,4’-tetraachlorobiphenyl on male reproductive system in offspring of rats”, 17th Asia Conference on Occupational Health, November 1-3, Taipei, Taiwan.
  16. Hsu, P.C.,Guo, Y.L., Huang, W., and Yao, WJ (2002) “Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans”, 17th Asia Conference on Occupational Health, November 1-3, Taipei, Taiwan.
  17. Chu, H.C., Huang, C.T., and Hsu, P.C.* (2003) “Effects of hydrogen peroxide exposure on apoptosis induction by increasing mitochondrial membrane potential in human spermatozoa”, 18th Joint Annual Conference of Biomedical Science, March 22-23, Taipei, Taiwan.
  18. Huang, C.T., Chu, H.C., and Hsu, P.C.* (2003) “Effects of lead exposure on apoptosis and specific reactive oxygen species generation in rats spermatozoa”, 18th Joint Annual Conference of Biomedical Science, March 22-23, Taipei, Taiwan.
  19. Chu, H.C., Chen, J.R., Zhou, C.X., Huang, C.T., and Hsu, P.C.* (2003) “Effects of hydrogen peroxide exposure on inducing apoptosis and specific reactive oxygen species generation in human spermatozoa”, Congress on Industrial Hygiene, April 26-27, Taichung, Taiwan.
  20. Huang, C.T., Lin, C.N., Huang, C.M., Chu, H.C., and Hsu, P.C.* (2003) “Effects of lead exposure on mitochondrial function and apoptosis in rats spermatozoa”, Congress on Industrial Hygiene, April 26-27, Taichung, Taiwan.
  21. Wang, S.H., Hsu, P.C., Cheng, K.H., and Guo, Y.L. (2003) “Performance of biological safety and health training in biotechnology industry”, Congress on Industrial Hygiene, April 26-27, Taichung, Taiwan.
  22. Hsu P.C., Huang, W., Yao, W.J., Wu, M.H., Guo, Y.L., and Lambert, G.H. (2003) Comparison of the changes of sperm function between humans prenatally and postnatally exposed to polychlorinated biphenyls and dibenzofurans”, The 23th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 24-29, Boston, USA.
  23. Chien, S.U., Ling, T.C., Hsu, P.C. and Li, L.A. (2004) “AhR antagonist 3’,4’-dimethoxyflavone enhance the PCB126-elited transcriptional induction of CYP11B1 and CYP11B2”, 19th Joint Annual Conference of Biomedical Science, April 10-11, Taipei, Taiwan.
  24. Chen, J.R., Li, L.A., Guo, Y.L. and Hsu, P.C.* (2004) “Effects of prenatal exposure to 2,2',3,3',4,6'-hexachlorobiphenyl on testicular apoptosis-related genes expression in adult rats”, Congress on Industrial Hygiene, April 24-25, Kaohsiung , Taiwan.
  25. Yang, S.M., Hsu, P.C., Wang, Y.J. and Guo, Y.L. (2004) “Sperm quality in male rat in uterus exposed to di(2-ethylhexyl) phthalate”, Congress on Industrial Hygiene, April 24-25, Kaohsiung , Taiwan.
  26. Hsu, P.C., Chen, C.J., Li L.A. and Guo, Y.L. (2004) “Effects of Early Postnatal Exposure of 2,2',3,3',4,6'-hexachlorobiphenyl on Apoptosis-related Gene Expression in Adult Rat Testis”, The 14th Annual Conference of International Society of Exposure Analysis, October 17-21, Philadelphia, USA.
  27. Hsu, P.C., Lai, T.J., Guo, N.W., Lambert, G.H., Guo, Y.L. (2004) “Serum hormones changes in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans”, The 3rd International Conference on Environmental Hormones and POPs, November 12, Taipei, Taiwan.
  28. Hsu, P.C. (2004) “Flow cytometric detection of microbial hydrogen production-The applications and limitations”, The 5th International Conference on Clean Energy, November 19, Kaohsiung, Taiwan.
  29. Chen, C.J., Li, L.A. and Hsu, P.C.* (2005) “Effects of prenatal exposure to 2,2’,3,3’,4,6’-hexachlorobiphenyl on testicular genes expression and histopathological changes in rats”, 20th Joint Annual Conference of Biomedical Science, March 26-27, Taipei, Taiwan.
  30. Wu, Y.Z., Hsu, P.C. and Li, M.G. (2005) “Analysis of butadiene monoxide and butadiene dioxide in mice urine by headspace solid phase microextraction and gas chromatography-mass spectrometry”, 20th Joint Annual Conference of Biomedical Science, March 26-27, Taipei, Taiwan.
  31. Chen, C.J., Li, L.A., Guo, Y.L., Pan, M.H. and Hsu, P.C.* (2005) “Effects of postnatal exposure to 3,3’,4,4’-tetrachlorobiphenyl on expression of apoptosis-related genes in testis”, Congress on Industrial Hygiene, April 29-May 1, Tainan , Taiwan.
  32. Chen, I.Y., Wu, M.T., Pan, C.H., Chen, C.J. and Hsu, P.C.* (2005) “Sperm functions of coke-oven workers exposed to polycyclic aromatic hydrocarbons”, Congress on Industrial Hygiene, April 29-May 1, Tainan , Taiwan.
  33. Chien, H.Y., Wang, Y.J., Hsu, P.C. and Guo, Y.L. (2006) “The male reproductive effect of exposure to PCB and smoking”, 21th Joint Annual Conference of Biomedical Science, March 18-19, Taipei, Taiwan.
  34. Hsu, C.L., Hsu, H.C., Guo, L.Y. and Hsu, P.C.* (2006) “Effects of prenatal exposure to di-n-butyl phthalate on reproduction and development in male adult rats”, 21th Joint Annual Conference of Biomedical Science, March 18-19, Taipei, Taiwan.
  35. Hsu, P.C.,* Chen, C.J., Li, L.A., Pan, M.H., Guo, Y.L. (2006) “Genetic biomarkers of endocrine disruptors in male reproductive toxicology”, International Conference of Industrial Hygiene and Occupational Medicine, April 28-29, Taipei, Taiwan.
  36. Hsiao, Y.C., Chen, J.R., Pan, C.H., Guo, Y.L., Pan, M.H., Hsu, P.C.* (2006) “Aresenic exposure metabolites, and immunological function in workers of copper-foil plant”, International Conference of Industrial Hygiene and Occupational Medicine, April 28-29, Taipei, Taiwan.
  37. Tseng, L.H., Lee, C.W., Tsai, S.S., Li, M.H., Hsu, H.C. and Hsu, P.C.* (2006) “Effects of in utero exposure to decabrominated diphenyl ether (PBDE 209) on reproductive function in the male mouse”, International Conference of Industrial Hygiene and Occupational Medicine, April 28-29, Taipei, Taiwan.
  38. Tseng, L.H., Lee, C.W., Pan, M.H., Tsai, S.S., Li, M.H., Chen, J.R., Lay, J.J., Hsu, P.C.* (2006) “Postnatal exposure of the male mouse to 2,2’,3,3’,4,4’,5,5’,6,6’-decabrominated diphenyl ether: decreased epididymal sperm functions without alterations in DNA content and histology in testis”, The First East Asia Conference of the ISEE, April 28-30, Taipei, Taiwan.
  39. Hsu, P.C.,* Chen, C.J., Li, L.A., Pan, M.H., Guo, Y.L. (2006) “Effects of neonatal exposure of 2,2',3,3',4,6'-hexachlorobiphenyl and 3,3’,4,4’-tetrachlorobiphenyl on apoptosis-related genes expression in rat testis”, The First East Asia Conference of the ISEE, April 28-30, Taipei, Taiwan.
  40. Hsu, P.C.*, Chen, C.J., Li, L.A., Pan, M.H., Guo, Y.L. (2006) “Effects of prenatal exposure of 2,2',3,3',4,6'-hexchlorobiphenyl on sperm function and genes expression in rats”, The 26th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 21-25, Oslo, Norway.
  41. Hsu, P.C.*, Tseng, L.H., Lee, C.W. (2006) “Effects of prenatal exposure of decabrominated diphenyl ether (PBDE 209) on reproductive system in male mice”, The 26th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 21-25, Oslo, Norway.
  42. Tseng, L.H., Li, M.H., Hsu, P.C.*, Lee, C.W. (2006) “Effects of in utero exposure to decabrominated diphenyl ether (PBDE 209) on developmental toxicity and liver enzyme activities in male mice”, The 26th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 21-25, Oslo, Norway.
  43. Tseng, L.H., Hsu, P.C.*, Lee, C.W., Tsai, S.S. (2007) “In utero exposure to PBDE 209: Induced sperm and testis dysfunction in male offspring mice”, Congress on Industrial Hygiene, April 21-22, Kaohsiung, Taiwan.
  44. Liu, Y.C., Hsu, P.C.*, Chang, H.Y., Lee, C.W., Shih, T.H., Pan M.H., Lai, C.H. (2007) “The study of immunological function and reactive oxygen species generation of white blood cells in steal plant workers”, Congress on Industrial Hygiene, April 21-22, Kaohsiung, Taiwan.
  45. Chang, Y.F., Hsu, P.C.*, Pan, M.H., Huang, Y.T., Lai, C.S., Kuo, P.L. (2007) “Di-n-butyl phthalate induces cell cycle arrest in mice spermatogonia cells”, Congress on Industrial Hygiene, April 21-22, Kaohsiung, Taiwan.
  46. Liau, G.S., Hsu, P.C.*, Chang, H.Y., Pan, M.H., Lai, C.S., Huang, Y.T., Kuo, P.L. (2007) “N-acetyl- S-(N-methylcarbamoyl)cysteine induces cytotoxicity in mice spermatogonia cells”, Congress on Industrial Hygiene, April 21-22, Kaohsiung, Taiwan.
  47. Hsu, P.C.*, Guo, Y.L., Lambert, G.H. (2007) “Rproductive and hormone homeostasis effects in Yucheng men exposed to PCBs/PCDFs”, The 27th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, September 2-7, Tokyo, Japan.
  48. Hsu, P.C.*, Chen J.J., Li, L.A., Guo, Y.L. (2007) “Comparison of changes of testicular gene expression between rats neonatally exposed to coplanar (PCB 77) and non-coplanar (PCB 132) polychlorinated biphenyl congeners”, The 27th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, September 2-7, Tokyo, Japan.
  49. Tseng L.H., Hsu, P.C.*, Li, M.H., Lee, C.W. (2007) “Neonatal exposure to decabrominated diphenyl ether (PBDE 209) impaired morphology of hepatocytes but did not affect hepatic enzyme activities and thyroid hormones homeostasis in the adult mouse”, The 27th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, September 2-7, Tokyo, Japan.
  50. Hsu, P.C., Chang, H.Y., Guo, Y.L., Shih, T.S. (2008) “Interaction of smoking and lead exposure affects reproductive function in male workers”, International Occupational Hygiene Association 7th International Scientific Conference, February 18-22, Taipei, Taiwan.
  51. Hsu, P.C., Chang, H.Y., Lee, C.W., Liu, Y.C., Shih, T.S. (2008) “Changes of immunological function and reactive oxygen species generation of white blood cells in coal chemicals workers in Taiwan”, International Occupational Hygiene Association 7th International Scientific Conference, February 18-22, Taipei, Taiwan.
  52. Chang, K.D., Hsu, P.C.,* Chang, H.Y., Lee, C.W., Shih, T.S., Hsieh, M.Y., Yen, T.L. (2008) “Semen quality and urinary metabolites of benzene and naphthalene in coal chemicals workers in Taiwan”, International Occupational Hygiene Association 7th International Scientific Conference, February 18-22, Taipei, Taiwan.
  53. Yen, T.L., Hsu, P.C.,* Guo, Y.L., Pan, M.H., Hsieh, M.Y., Chang, K.D. (2008) “Effects of in uteral, lactational and prepubertal DBP and/or DEHP exposure on male development and reproduction”, International Occupational Hygiene Association 7th International Scientific Conference, February 18-22, Taipei, Taiwan.
  54. Hsieh, M.Y., Hsu, P.C.,* Guo, Y.L., Pan, M.H., Yen, T.L., Chang, K.D. (2008) “Transgenerational actions of DEHP and/or DBP exposure on development and reproduction in F2 generation male rats”, International Occupational Hygiene Association 7th International Scientific Conference, February 18-22, Taipei, Taiwan.
  55. Hsu, P.C.*, Guo, Y.L., Yen T.L., Hsieh, M.Y., Chang, K.D., Pan, M.H. (2008) “Synergistic effect of DBP and DEHP combined exposure on male development and reproduction”, The 28th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 17-22, Birmingham, UK.
  56. Tseng L.H., Hsu, P.C.*, Li, M.H., Lee, C.W. (2008) “Development and hepatic enzymes activities in female mice prenatally exposed to decabrominated diphenyl ether (PBDE 209)”, The 28th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants, August 17-22, Birmingham, UK.
  57. Hsu, P.C.,* Guo, Y.L., Lambert, G.H., Li, M.H., Pan, M.H., Tsai, S.S., Li, L.A. (2008) “Effects of environmental endocrine disruptors on male reproductive functions”, International Conference on Environmental Hormones and Health Effects, December 5-6, Taipei, Taiwan.
  58. Hsu, C.L., Hsu, H.C., Li, Guo, Y.L. and Hsu, P.C.* (2008) “Effects of prenatal exposure to di-n-butyl phthalate on reproduction and development system in male offspring”, International Conference on Environmental Hormones and Health Effects, December 5-6, Taipei, Taiwan.
  59. Lee, C.H., Chen, L.W., Tseng, L.H., Hsu, P.C.* (2009) “Exposure in utero to tetrabromined diphenyl Ether (BDE-47) impairs development and reproductive function in mice offspring”, 2009 Industrial Hygiene and Occupational Medicine Conference, April 25-26, Taichung, Taiwan.
  60. Chen, L.W., Chang, S.H., Lee, C.H., Tseng, L.H., Ho, Y.J., Hsu, P.C.* (2009) “Evaluation of spontaneous behavior, learning and memory in adult male mice prenatally exposed to PBDE-47”, 2009 Industrial Hygiene and Occupational Medicine Conference, April 25-26, Taichung, Taiwan.
  61. Chang, S.H., Tseng, L.H., Ho, Y.J., Hsu, P.C. Chen, L.W., Shao, Y.R. (2009) “Effects of neonatal exposure to decabromined diphenyl ether on spontaneous behavior in mice”, 2009 Industrial Hygiene and Occupational Medicine Conference, April 25-26, Taichung, Taiwan.
  62. Lung, T.Y., Wu, Y.H., Hsu, P.C., Liu, J.Y., Tseng, L.H. (2009) “Early neurobehavioral effects in mice offspring after maternal exposed to Effects of neonatal exposure to decabromined diphenyl ether (PBDE 209)”, 2009 Industrial Hygiene and Occupational Medicine Conference, April 25-26, Taichung, Taiwan.
  63. Hsu, P.C.,* Guo, Y.L., Lambert, G.H., Li, M.H., Pan, M.H., Tsai, S.S., Li, L.A. (2009) “Environmental endocrine disruptors and male reproductive hazards”, 2009 International Symposium on Emerging Compounds: Measurement and Control, May 26, Pingtung, Taiwan.

專書

  1. 許昺奇、郭育良 (2002) 職業性生殖系統疾病．In: 郭育良，eds. 職業病概論．華杏出版公司，台北
  2. 許昺奇 (2003) 吸菸對性功能與生殖之影響．國家衛生研究院論壇，台北

 

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